2009.05.28 – A Common Genetic Mechanism in Malignant Bone Marrow Diseases

http://content.nejm.org/cgi/content/short/360/22/2355

A Common Genetic Mechanism in Malignant Bone Marrow Diseases

New England Journal of Medicine (subscription) – MA,USA

A principal feature of the myeloproliferative disorders, which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis,

Volume 360:2355-2357: May 28, 2009, Number 22

A Common Genetic Mechanism in Malignant Bone Marrow Diseases
Ross L. Levine, M.D., and Martin Carroll, M.D.

Since this article has no abstract, we have provided an extract

of the first 100 words of the full text and any section headings.

The myelodysplastic syndromes, myeloproliferative disorders, and acute myeloid leukemia (AML) are seemingly unrelated diseases except for their origin in hematopoietic precursor cells in bone marrow. A principal feature of the myeloproliferative disorders, which include polycythemia vera, essential thrombocythemia, and primary myelofibrosis, is overproduction of blood cells. By contrast, a prominent feature of the myelodysplastic syndromes is a reduction in the number of one or more cells in the hematopoietic lineage. In AML, primitive myeloid cells in the bone marrow do not differentiate into mature granulocytes. These three groups of bone marrow disorders are distinct, yet they have overlapping features. Moreover, . . . [Full Text of this Article]


Source Information

From the Human Oncology and Pathogenesis Program and the Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York (R.L.L.); and the Division of Hematology and Oncology, University of Pennsylvania, Philadelphia (M.C.).

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